Hormonal regulation of the insulin-responsive glucose transporter, GLUT4: some recent advances.
نویسندگان
چکیده
BY C A L L U M LIVINGSTONE, F I O N A J . T H O M S O N , M A R G A R E T I . A R B U C K L E , I A N W. CAMPBELL, THOMAS J . JESS , SUSAN K A N E , COLIN MOYES, LISA M. P O R T E R , J A C Q U E L I N E E . R I C E , M I C H A E L J . S E A T T E R A N D GWYN W. G O U L D Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ
منابع مشابه
Hormonal regulation of the insulin-responsive glucose transporter, GLUT4: some recent advances
BY C A L L U M LIVINGSTONE, F I O N A J . T H O M S O N , M A R G A R E T I . A R B U C K L E , I A N W. CAMPBELL, THOMAS J . JESS , SUSAN K A N E , COLIN MOYES, LISA M. P O R T E R , J A C Q U E L I N E E . R I C E , M I C H A E L J . S E A T T E R A N D GWYN W. G O U L D Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G...
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The insulin-responsive glucose transporter 4 (GLUT4) plays a key role in glucose uptake and metabolism in insulin target tissues. Being a rate-limiting step in glucose metabolism, the expression and function of the GLUT4 isoform has been extensively studied and found to be tightly regulated at both mRNA and protein levels. Adaptation to states of enhanced metabolic demand is associated with inc...
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GLUT4 has long been known to be an insulin responsive glucose transporter. Regulation of GLUT4 has been a major focus of research on the cause and prevention of type 2 diabetes. Understanding how insulin signaling alters the intracellular trafficking of GLUT4 as well as understanding the fate of glucose transported into the cell by GLUT4 will be critically important for seeking solutions to the...
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متن کاملInsulin down-regulates expression of the insulin-responsive glucose transporter (GLUT4) gene: effects on transcription and mRNA turnover.
Insulin rapidly represses expression of the gene encoding the insulin-responsive glucose transporter (GLUT4) in 3T3-L1 mouse adipocytes. Upon exposure to the hormone the cellular level of GLUT4 mRNA falls (t1/2 approximately 2.5 hr) to 20-30% of its initial level within 10 hr. This is followed by a similar decrease in the level of GLUT4 protein. Down-regulation of GLUT4 mRNA is a result of both...
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ورودعنوان ژورنال:
- The Proceedings of the Nutrition Society
دوره 55 1B شماره
صفحات -
تاریخ انتشار 1996